Table 1

Tests of thyroid function in leptin-deficient adults, before and after treatment with r-metHuLeptin.

Before leptin

One year after

Two years after

Four years after

Six years after

Six years after (off leptin)

Seven years after

Eight years after


TSH (mU/L)

A

3.8

*

4.5

4.17

*

*

*

*


B

0.93

1.1

*

0.64

1.68

1.26

0.68

1.38


C

1.5

*

*

*

1.09

1.61

1.27

1.0


D

2.4

0.88

*

0.47

0.83

1.15

1.52

1.23


Total T4

(μg/dl)

A

5.4

*

8.8

*

*

*

*

*


B

6.9

6.9

*

9.1

7.5

7.6

*

*


C

8.4

*

*

*

8.0

8.4

*

*


D

5.2

7.9

*

10.9

7.5

6.5

*

*


Total T3

(ng/dl)

A

*

*

*

*

*

*

*

*


B

114

112

167

121

121

*

*

*


C

118

*

*

*

112

118

*

*


D

76

125

*

110

122

106

*

*


Free T4

(ng/dl)

A

1.3

*

1.2

1.49

*

*

*

*


B

*

*

*

*

1.0

*

0.9

1.34


C

*

*

*

*

1.1

1.3

0.8

1.47


D

*

*

*

*

1.1

1.0

0.73

1.16


BMI (kg/m2)

A

39.6

24.8

23.8

22.6

*

*

*

*


B

51.4

24.5

22.6

23.7

23.3

26.7

25.8

25.4


C

46.7

26.0

26.0

25.0

26.7

29.0

30.3

32.2


D

55.4

35.0

28.0

31.7

33.3

36.2

32.5

36.5


* Not available

Reference ranges: TSH: 0.40-4.0 mU/L; total T4: 4.5-12.5 μg/dl; total T3: 75-178 ng/dl; free T4: 0.7-2.1 ng/dl

Paz-Filho et al. Thyroid Research 2009 2:11   doi:10.1186/1756-6614-2-11

Open Data