Table 1

Tests of thyroid function in leptin-deficient adults, before and after treatment with r-metHuLeptin.


Before leptin
 One year after
 Two years after
 Four years after
 Six years after
 Six years after (off leptin)
 Seven years after
 Eight years after
TSH (mU/L)
 A
 3.8
 *
 4.5
 4.17
 *
 *
 *
 *


B
 0.93
 1.1
 *
 0.64
 1.68
 1.26
 0.68
 1.38


C
 1.5
 *
 *
 *
 1.09
 1.61
 1.27
 1.0


D
 2.4
 0.88
 *
 0.47
 0.83
 1.15
 1.52
 1.23
Total T4
(μg/dl)
 A
 5.4
 *
 8.8
 *
 *
 *
 *
 *


B
 6.9
 6.9
 *
 9.1
 7.5
 7.6
 *
 *


C
 8.4
 *
 *
 *
 8.0
 8.4
 *
 *


D
 5.2
 7.9
 *
 10.9
 7.5
 6.5
 *
 *
Total T3
(ng/dl)
 A
 *
 *
 *
 *
 *
 *
 *
 *


B
 114
 112
 167
 121
 121
 *
 *
 *


C
 118
 *
 *
 *
 112
 118
 *
 *


D
 76
 125
 *
 110
 122
 106
 *
 *
Free T4
(ng/dl)
 A
 1.3
 *
 1.2
 1.49
 *
 *
 *
 *


B
 *
 *
 *
 *
 1.0
 *
 0.9
 1.34


C
 *
 *
 *
 *
 1.1
 1.3
 0.8
 1.47


D
 *
 *
 *
 *
 1.1
 1.0
 0.73
 1.16
BMI (kg/m2)
 A
 39.6
 24.8
 23.8
 22.6
 *
 *
 *
 *


B
 51.4
 24.5
 22.6
 23.7
 23.3
 26.7
 25.8
 25.4


C
 46.7
 26.0
 26.0
 25.0
 26.7
 29.0
 30.3
 32.2


D
 55.4
 35.0
 28.0
 31.7
 33.3
 36.2
 32.5
 36.5

* Not available

Reference ranges: TSH: 0.40-4.0 mU/L; total T4: 4.5-12.5 μg/dl; total T3: 75-178 ng/dl; free T4: 0.7-2.1 ng/dl

Paz-Filho et al. Thyroid Research 2009 2:11   doi:10.1186/1756-6614-2-11

Open Data