Table 1 |
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|
Expression of NIS in different tissues and its regulation by different thyroid statuses |
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|
NIS |
TSHR |
TTF1 |
Pax8 |
TH response |
|
|
|
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|
Stomach |
+++ |
+ |
- |
- |
No |
|
Thyroid |
+++ |
+++ |
+ |
+ |
Yes |
|
Submandibular gland |
++ |
+ |
- |
- |
No |
|
Colon |
+ |
+ |
- |
- |
No |
|
Testis |
+ |
++ |
- |
- |
No |
|
Lung |
+ |
+ |
+ |
- |
Inverse |
|
Liver |
- |
+ |
- |
- |
No |
|
Pancreas |
- |
+ |
- |
- |
No |
|
|
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|
In the columns of NIS and TSHR, relative transcription levels obtained from end-point RTPCR are displayed as '+++', '++', '+' in descending order of expression, and negative expression is displayed as '-'. In the columns of TTF1 and Pax8, presence or absence of transcription are displayed as '+' and '-', respectively. Existence of thyroid-like responsiveness of NIS mRNA expression to thyroid hormone (up-regulated against methimazole and down-regulated against L-T4) is displayed as 'Yes', no-regulatory effect is displayed as 'No', and responsiveness in an inverse direction to thyroid (down-regulated against methimazole and up-regulated against L-T4) is displayed as 'Inverse' in the column of TH response. 'TH' stands for thyroid hormone. |
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|
Harun-Or-Rashid et al. Thyroid Research 2010 3:3 doi:10.1186/1756-6614-3-3 |
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